解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14040078
更新日期:2016-04-13 00:00:00
abstract::We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of a paralytic toxin, but...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14040063
更新日期:2016-03-25 00:00:00
abstract::The marine environment is host to unparalleled biological and chemical diversity, making it an attractive resource for the discovery of new therapeutics for a plethora of diseases. Compounds that are extracted from cyanobacteria are of special interest due to their unique structural scaffolds and capacity to produce p...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14010017
更新日期:2016-01-12 00:00:00
abstract::We have searched for special characteristics in growth, protein expression, fatty acids and volatile organic compounds (VOCs) in a local Phaeodactylum tricornutum Bohlin strain (Bergen Marine Biobank), by comparing it with a common accession strain (CCAP). Differences in growth and expressed proteins were detected bet...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14010009
更新日期:2015-12-30 00:00:00
abstract::Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14010001
更新日期:2015-12-22 00:00:00
abstract::MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3: Galα1-4Galβ1-4Glc). MytiLec revealed β-trefoil folding as also found in the ricin B-subunit type (R-type) lectin family, although the amino acid sequences were quite different....
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13127071
更新日期:2015-12-14 00:00:00
abstract::Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13127064
更新日期:2015-12-05 00:00:00
abstract::The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13117040
更新日期:2015-11-19 00:00:00
abstract::Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13116884
更新日期:2015-11-13 00:00:00
abstract::After in situ incubation at the site for a year, phytoplanktons in surface water were exposed to natural light in temperate lakes (every month); thereafter, the net production rate of photoprotective compounds (mycosporine-like amino acids, MAAs) was calculated using (13)C labeled tracer. This is the first report desc...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13116740
更新日期:2015-11-06 00:00:00
abstract::Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13116687
更新日期:2015-10-30 00:00:00
abstract::In the course of our continuing efforts to identify bioactive secondary metabolites from Red Sea marine invertebrates, we have investigated the sponge Hemimycale arabica. The antimicrobial fraction of an organic extract of the sponge afforded two new hydantoin alkaloids, hemimycalins A and B (2 and 3), together with t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13116609
更新日期:2015-10-28 00:00:00
abstract::The ability to produce an extracellular matrix and form multicellular communities is an adaptive behavior shared by many bacteria. In Bacillus subtilis, the model system for spore-forming bacteria, matrix production is one of the possible differentiation pathways that a cell can follow when vegetative growth is no lon...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13106472
更新日期:2015-10-21 00:00:00
abstract::Bioassay-guided evaluation shows that a deep sea-derived fungus, Spiromastix sp. MCCC 3A00308, possesses lipid-lowering activity. Chromatographic separation of a culture broth resulted in the isolation of 15 known depsidone-based analogues, labeled spiromastixones A-O (1-15). Each of these compounds was tested for its...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13106352
更新日期:2015-10-14 00:00:00
abstract::The discovery of new bioactive compounds from marine natural sources is very important in pharmacological research. Here we developed a Wnt responsive luciferase reporter assay to screen small molecule inhibitors of cancer associated constitutive Wnt signaling pathway. We identified that gliotoxin (GTX) and some of it...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13106259
更新日期:2015-10-02 00:00:00
abstract::Carotenoids are lipid-soluble pigments that are produced in some plants, algae, fungi, and bacterial species, which accounts for their orange and yellow hues. Carotenoids are powerful antioxidants thanks to their ability to quench singlet oxygen, to be oxidized, to be isomerized, and to scavenge free radicals, which p...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13106226
更新日期:2015-09-30 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a malignant tumor that can cause systemic invasion; however, the exact etiology and molecular mechanism are unknown. Astaxanthin (ASX), a powerful antioxidant, has efficient anti-oxidant, anti-inflammatory, and other activities, and has great research prospects in cancer therapy. We s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13106064
更新日期:2015-09-24 00:00:00
abstract::The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we e...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13095947
更新日期:2015-09-18 00:00:00
abstract::Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13095784
更新日期:2015-09-15 00:00:00
abstract::Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13085447
更新日期:2015-08-21 00:00:00
abstract::The mucus produced by many marine organisms is a complex mixture of proteins and polysaccharides forming a weak watery gel. It is essential for vital processes including locomotion, navigation, structural support, heterotrophic feeding and defence against a multitude of environmental stresses, predators, parasites, an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13085276
更新日期:2015-08-19 00:00:00
abstract::Hepatic fibrosis is an effusive wound healing process, characterized by an excessive deposition of extracellular matrix (ECM), as the consequence of chronic liver injury of any etiology. Current therapeutic repertoire for hepatic fibrosis is limited to withdrawal of the noxious agent, which is not always feasible. Hen...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13085201
更新日期:2015-08-18 00:00:00
abstract::A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes. An original branched conjugated fatty acid, mainly present in triglyc...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13084934
更新日期:2015-08-06 00:00:00
abstract::Lipid A is a fundamental Gram-negative outer membrane component and the essential element of lipopolysaccharide (endotoxin), a potent immunostimulatory molecule. This work describes the metabolic adaptation of the lipid A acyl structure by Psychrobacter cryohalolentis at various temperatures in its facultative psychro...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13084701
更新日期:2015-07-30 00:00:00
abstract::The marine ecosystem has been a key resource for secondary metabolites with promising biological roles. In the current study, bioassay-guided phytochemical investigations were carried out to assess the presence of enzyme inhibitory chemical constituents from the methanolic extract of marine green alga-Codium dwarkense...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13074344
更新日期:2015-07-14 00:00:00
abstract::The A. salmonicida A450 LPS O-antigen, encoded by the wbsalmo gene cluster, is exported through an ABC-2 transporter-dependent pathway. It represents the first example of an O-antigen LPS polysaccharide with three different monosaccharides in their repeating unit assembled by this pathway. Until now, only repeating un...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13063791
更新日期:2015-06-15 00:00:00
abstract::Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13063567
更新日期:2015-06-05 00:00:00
abstract::Numerous studies have suggested that hyperlipidemia is closely linked to cardiovascular disease. The aim of this study was to investigate the possible antihyperlipidemia mechanism of HU (high sulfate content of ulvan) in high-cholesterol fed rats. Wistar rats were made hyperlipidemic by feeding with a high-cholesterol...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13063407
更新日期:2015-05-29 00:00:00
abstract::Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications. The annual global production of these hydrocolloids has recently reached 100,000 tons with a gross market value just above US$ 1....
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13063340
更新日期:2015-05-27 00:00:00
abstract::Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13053103
更新日期:2015-05-19 00:00:00
abstract::Marine derived cyclo(Gly-l-Ser-l-Pro-l-Glu) was selected as a lead to evaluate antitumor-antibiotic activity. Histidine was chosen to replace the serine residue to form cyclo(Gly-l-His-l-Pro-l-Glu). Cyclic tetrapeptides (CtetPs) were then synthesized using a solution phase method, and subjected to antitumor and antibi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13053029
更新日期:2015-05-15 00:00:00
abstract::The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13052924
更新日期:2015-05-13 00:00:00
abstract::The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13052875
更新日期:2015-05-08 00:00:00
abstract::The development of oxidative stress in the marine ecosystem is a concurring concern in fish reproductive behavior. Marine fish being rich in polyunsaturated fatty acids (PUFA) are precursors of prostaglandin pheromone mediators but also vulnerable to lipid peroxidation. It is yet to be determined if hypoxia or hyperox...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13042215
更新日期:2015-04-14 00:00:00
abstract::Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine organisms; it is a strong antioxidant and exhibits othe...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13042105
更新日期:2015-04-13 00:00:00
abstract::This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13041739
更新日期:2015-03-30 00:00:00
abstract::Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members. These proteins remain stably folded in water, but upon interaction with lipid bilayers, they oligomerize to form a po...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13041647
更新日期:2015-03-25 00:00:00
abstract::The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13031552
更新日期:2015-03-20 00:00:00
abstract::β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups,...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13031185
更新日期:2015-03-02 00:00:00
abstract::The red seaweeds belonging to the genus Laurencia are well known as halogenated secondary metabolites producers, mainly terpenoids and acetogennins. Several of these chemicals exhibit important ecological roles and biotechnological applications. However, knowledge regarding the genes involved in the biosynthesis of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020879
更新日期:2015-02-10 00:00:00